Sunday, May 11, 2014

True Increase in Thyroid Cancer Incidence? Maybe not

Many data registries have shown an increasing trend in thyroid cancer incidence, however it is questionable as to whether the numbers are due to an actual increase in incidence or due to and increase in detection of pre-existing cancers because of an improvement and increase in cancer screening techniques. Dr. Louise Davies and Dr. H. Gilbert Welch have investigated the cause of this increasing trend through data analysis and have published their findings1. This pattern is further investigated by a separate Q and A article2 published by Yasuhiro Ito, Yuri E. Nikiforov, Martin Schlumberger, and Riccardo Vigneri. Both works do not completely rule out the idea that incidence of thyroid cancer is increasing, however they both support the claim that the trend is most likely due to an increase in detection of the cancer through improved diagnostic procedures.
  While the data on thyroid cancer overall seems to point to an increase in incidence, there are many other patterns within the data that do not correspond with this assumption. For instance, if it were true that more and more people are acquiring thyroid cancer, there would be an increase in incidences across all stages of the cancer, this however is not the case. Looking at Figure 1. 1, Davies and Welch observe that the increase is mostly due to the increase in smaller sizes and lower stages of cancer1. Furthermore, if there were a true increase, there would be an increase in suspected risk factors of the cancer, in this case radiation, which is not the case since radiation exposure is less common today, as therapeutic radiation for common diseases has not been used since the 1950s1.
Even looking back 50 years ago, pathologists recorded that thyroid cancers were commonly found during autopsies even when the deceased had never reported any of the symptoms during their life1. This indicates that there were many more incidences of thyroid cancer in the past that have gone unreported. The reason that they are showing up now is due to the improvement in the sensitivity of diagnostic techniques. These techniques include ultrasound and fine needle aspiration (biopsy) which are able to detect tumors as small as 0.2cm (symptoms generally occur for tumors larger than 5cm)1.
The increase is observed in countries with improved medical care, while in countries of Africa, where the medical care is not so available, this increase has not been seen. Furthermore there is a positive correlation between high socioeconomic status and thyroid cancer incidence. Countries with good healthcare and households with high socioeconomic status have the resources to make these new diagnostic techniques available to them and therefore they detect more incidences of thyroid cancers2.
A true increase would also show an increase in mortality rates due to thyroid cancer which is not the case as seen in Figure 21. The stable mortality and increasing incidence is observed because the slope is mainly due to the increased detection of small asymptomatic tumors by the sensitive diagnostic  techniques. This is not to say that all small thyroid tumors are asymptomatic, more aggressive types of thyroid cancers (follicular and poorly differentiated) can be symptomatic even at small sizes, however an increase in incidences among these types is not observed (Figure 1.)1.
All these factors indicate that the increase in incidence is due to the increase in cancer detection and not so much an increase in accumulation of the cancer. The controversy surrounding this viewed increase in incidence is the problem of overdiagnosis. As exemplified from the findings of cancers in the autopsies, many of the small thyroid cancers will never become symptomatic in a persons lifetime, however today, these asymptomatic cancers are being  treated as they are detected. The main treatment for thyroid cancer is a thyroidectomy, which is the surgical removal of all or parts of the thyroid gland3.  The risks for this procedure include hypoparathyroidism and compromised voice quality1, a high expense for a treatment of an asymptomatic nodule. To decrease overdiagnosis, the American Thyroid Association recommends that fine needle aspiration biopsies only be performed on nodules larger than 5mm2. They also recommend that, instead of treatment of smaller thyroid cancers, yearly or biannual follow ups should be performed, with surgery only suggested if the cancer shows signs that is it progressing (i.e. size increase)2.





[1]Davies, Loiuse MD,MS; Welch, Gilbert H. "Increasing Incidence of Thyroid Cancer in the United States, 1973-2002. JAMA, May 10, 2006-Vol 295, No. 18 (Reprinted).

[2]Ito, Y. et al. "Increasing incidence of thyroid cancer: controversies explored"  Nat. Rev. Endocrinol. 9, 178-184 (2013); published online 29 Jan 2013.

[3] N.A. "Q and A: Thyroidectomy". American Thyroid Association. August 2008. web. May 11 2014.